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Dropping down in nicotine strength can change the overall taste of an e-liquid. Nicotine can lend an inherently "peppery" or "spicy" flavor profile. This is especially apparent in the 18mg  to 12mg and 12mg to 6mg transitions. Due to this, Flavors may taste slightly different depending on what nicotine strength you choose. Please keep this in mind if you decide to drop your nicotine strength on a flavor with which you're familiar.